D Ave, Madison, WI 53792-3252; Division of Radiology, University of Yamanashi, Yamanashi, Japan (U.M., K.S.); and Division of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (P.B.)AbstractPurpose–To investigate the reason for imaging artifacts observed throughout gadoxetic acid nhanced arterial phase imaging of your liver. Materials and Methods–This HIPAA-compliant study was approved by the institutional overview board. Data were collected prospectively at two web sites (site A, United states; web-site B, Japan) from sufferers undergoing contrast material nhanced MR imaging with gadoxetic acid (web-site A, n = 154, dose = 0.05 mmol/kg; internet site B, n = 130, 0.025 mmol/kg) or gadobenate dimeglumine (only web site A, n = 1666) from January 2014 to September 2014 at site A and from November 2014 to January 2015 at web page B. Detailed comparisons among the two agents have been made in the patients with dynamic liver acquisitions (n = 372) and age-, sex-, and baseline oxygen saturation (Spo2)matched pairs (n = 130) at web site A. Acquired information integrated self-reported dyspnea immediately after contrast agent injection, Spo2, and breath-hold fidelity monitored with respiratory bellows. Results–Self-reported dyspnea was extra frequent with gadoxetic acid than with gadobenate dimeglumine (internet site A, 6.five [10 of 154] vs 0.1 [two of 1666], P .001; web site B, 1.5 [two of 130]). Within the matched-pair comparison, gadoxetic acid, as compared with gadobenate dimeglumine, had higher breath-hold failure prices (web site A, 34.six [45 of 130] vs 11.7 [15 of 130], P .0001; website B, 16.two [21 of 130]) and much more serious artifacts through arterial phase imaging (web-site A, 7.7 [10 of 130] vs 0 [none of 130], P .001; site B, 2.three [three of 130]). Extreme imaging artifacts in patients who received gadoxetic acid had been substantially associated with maleAddress correspondence to U.M. ([email protected]). Author contributions: Guarantors of integrity of entire study, U.M., S.B.R.; study concepts/study style or data acquisition or data analysis/interpretation, all authors; manuscript drafting or manuscript revision for essential intellectual content material, all authors; manuscript final version approval, all authors; agrees to make sure any queries associated towards the work are appropriately resolved, all authors; literature study, U.M., P.B., S.B.R.; clinical studies, all authors; statistical analysis, U.M., S.B.R.; and manuscript editing, U.M., P.B., C.A.B., S.B.R. Disclosures of Conflicts of Interest: U.M. disclosed no relevant relationships. P. B. disclosed no relevant relationships. C.A.B. disclosed no relevant relationships. K.S. disclosed no relevant relationships. S.B.R. Activities connected towards the present post: disclosed no relevant relationships.2223047-95-6 Chemscene Activities not related towards the present write-up: institution receives study assistance from Bracco Diagnostics and GE Healthcare.3-Chloro-1H-pyrazole uses Other relationships: disclosed no relevant relationships.PMID:25147652 On-line supplemental material is accessible for this article.Motosugi et al.Pagesex (P = .023), physique mass index (P = .021), and breath-hold failure (P .001) but not with dyspnea or Spo2 lower. Conclusion–Severe motion-related artifacts within the arterial phase of gadoxetic acid nhanced liver MR imaging are related with breath-hold failure but not with subjective feelings of dyspnea or maybe a substantial decrease in blood Spo2. Subjective feelings of dyspnea usually are not necessarily connected with imaging artifacts. The phenomenon, albeit at a reduced price, was confirmed at a second.